Barbara Weir was born in 1940 at what was formerly known as Derry Downs Station in the region of Utopia, North East of Alice Springs; her mother the late Minnie Pwerle, renowned Utopia and Australian artist, and her father an Irish station owner Jack Weir.

Being of mixed heritage Barbara was hidden from welfare patrol from the age of two and 'grown up' by her Aunty, the most famed female Aboriginal artist of all time, the late Emily Kame Kngwarreye. At the age of nine Barbara was taken away from her family by welfare while collecting water at Utopia Station, now known as Utopia Homestead. She is one of the people known as the 'stolen generation'. Barbara was taken to Bungalow (now known as the Telegraph Station) to get cleaned up, and then taken to St Mary's Home in Alice Springs. She was later moved to various children's homes around Australia, first in Victoria followed by the Receiving Home in Darwin and the Good Shepherd Home in Ipswich, before eventually returning to Darwin. During these years she was forced to speak English and forget her native tongue, and was told that her mother was dead. Though she lost contact with her family she was determined to return to them, to show she was alive and reclaim her heritage.

In the late 1960's Barbara was fortunate to find her family and returned to Utopia, the land of her birth, with her three children. The reunion was a happy one, but it was marred by the fact that Barbara was unable to communicate with the family, as she did not speak the language. Over the course of the next two and a half decades, Barbara had three more children and mastered both the Anmatyerre and Alyawarre languages and is one of the few people to do so from scratch.

On returning to her home and her unique relationship with Emily Kame Kngwarreye (who was then a well known batik artist) Barbara became interested in painting and showed a flair and talent for the art. In 1994, Barbara and other Aboriginal women travelled to Indonesia to learn more about the art of batik. The Utopia women were well known for their beautiful batiks as this contributed to the Aboriginal community buying back the region of Utopia in 1974 and making it their own.