Kylie is the daughter of Janice Clarke Kngwarreye and Wally Clarke Pwerle, both Utopia artists.

Kylie has been painting since early 1998 and has also worked with wood sculptures. Her work is extremely refined with intricate dot work and detailed studies of bush flowers, camp stories and designs associated with the stories from her country. Kylie would have observed and assisted with family painters as part of her training, which includes her grandmother Katie Kemarre, in particularly the Lyaw story. The intricate fine dot work is strongly influenced by her mother's painting style.