Doreen's mother was Lena Pwerle (dec) and her father, Left Hand Sam (1934-2002). She is married to Harold Payne Mpetyane and they have six children: Bronwyn, Violet, Richard, Johnny, Jimmy, Laura. All have painted or produced wood sculptures for Mbantua Gallery.

Doreen's paintings can comprise of colourful patterns of tiny dots when describing her country or the Yerrampe (Honey Ant) Story, or strong, bold, linear work when illustrating Awelye (Women's Ceremonial Body Paint Design). Her paintings always associate with the stories from her father's country, Ngkwarlerlaneme, North West of the Utopia Region.

Doreen's first work for Mbantua Gallery was wooden sculptures of birds, lizards and human figures painted up for ceremony, all of which involved a lot of skill - working the hard wood with tomahawk, rasp and file, then scraping the edges with broken glass to smooth the rough edges.